Will you need to know anything about Amazon VPC in order to use a default VPC?

No. You can use the AWS Management Console, AWS EC2 CLI, or the Amazon EC2 API to launch and manage EC2 instances and other AWS resources in a default VPC. AWS will automatically create a default VPC for you and will create a default subnet in each Availability Zone in the AWS region. Your default VPC will be connected to an Internet gateway and your instances will automatically receive public IP addresses, just like EC2-Classic.